Which filing system involves keeping one file for CDS-CII only?

The two-file system is designed specifically for managing controlled substances in a manner that complies with federal regulations. In this system, a pharmacy keeps two separate files for prescriptions: one for controlled substances in Schedules II and III and a second for all other medications.

By maintaining a separate file for Schedule II controlled substances (CDS-CII), which includes more tightly regulated drugs that have a higher potential for abuse, pharmacies can facilitate easier access for regulatory scrutiny while ensuring compliance with the law. This filing method allows for quicker retrieval of CII prescriptions when necessary, such as during inspections or audits, while also aiding in the overall management of inventory.

On the other hand, the one-file system would not be suitable for controlled substances, as it combines all prescriptions into a single file, which may lead to complications in tracking and compliance with federal regulations surrounding controlled substances. The three-file system adds an additional category, leading to a more complex filing approach than what is necessary for the regulations governing CDS-CII. The 'None of the above' option is not applicable because the two-file system specifically meets the context of the question. Thus, the correct approach is to use the two-file system for specific separation of controlled substances.